Defense
When fighting multiple opponents you suffer a defense penalty based on the number of opponents (unless you have the There is no Fork perk).
The defense penalty is -5 defnse levels for each opponent beyond the first (so -0 for 1 opponent, -10 for 2 opponents, -15 for 3 opponents, -20 for 4 opponents, …)
If you have the I Can't Dance perk you suffer an additional -15 defense level penalty if fighting more than one opponent (so -0 for 1 opponent, -25 for 2 opponents, -30 for 3 opponents, -35 for 4 opponents, …)